Chromatography

Approaches to Chromatography testing.

Gas Chromatography (GC): Gas Chromatography is used for analysis of mixtures of volatile and semi-volatile organic compounds (VOC’s and SVOC’s).  GC with flame ionization detection (FID) is commonly used for quantitative analysis of known target compounds.

Gas Chromatography-Mass Spectrometry (GC-MS): GC-MS is a powerful technique that can provide identification of unknowns in complex mixtures.  GC-MS is a great technique for analysis of trace level impurities such as residual monomers because of its excellent sensitivity and specificity.

Headspace Gas Chromatography: Headspace GC or GC-MS can be used to test for volatile organic compounds (VOC’s) such as residual solvents in solid or liquid samples.

In chemical analysis, chromatography is a laboratory technique for separating a mixture into its components. The mixture is dissolved in a liquid solvent called the mobile phase, which transports it through a system in which a material called the stationary phase is fixed.

High-Performance Liquid Chromatography (HPLC): Reverse-phase HPLC is used for testing of non-polar compounds such as polymer antioxidants and UV absorbers.  Normal phase HPLC and HILIC are also used depending on the polarity of the compounds of interest.


The goal of chromatography is to split the numerous materials that make up a mixture. The programs variety from a easy verification of the purity of a given compound to the quantitative dedication of the additives of a mixture.


Liquid Chromatography Mass Spectrometry (LC-MS): LC-MS combines the separation ability of HPLC with the identification capability of mass spectrometry.  LC-MS is useful for reformulation or extractable/leachable analysis of samples that may contain non-volatile additives or impurities.

The motive for variant withinside the granule intensity of the factor ratio in supported two-factor catalysts for the duration of their guidance has been studied. This phenomenon, which can be called “chromatographic effect”, relies upon at the unique affinities among substrate and ions withinside the impregnating solution.

5 Everyday uses for Chromatography


Size Exclusion Chromatography (SEC): Also known as Gel Permeation Chromatography (GPC), SEC is used to measure the molecular weight distribution of a polymer sample.  The molecular weight measurement may be performed using multi-angle light scattering (MALS) to obtain the absolute molecular weight.



Products we've analysed with Chromatography:







Medical devices:








Lactic acid and glycolic acid polymers (PLLA and PLGA) used in restorable medical implants, drug-eluting stents, and nanoparticles.  Polyesters, polyamides, polyurethanes, polyolefins, and silicone polymers used in medical packaging, tubing, and catheters.





Pharmaceutical products: 


Pharmaceutical packaging and delivery systems.  Controlled release formulations.  Pharmaceutical actives, intermediates, raw materials, and combination devices.